Abstract
Case 1: Serous tubal cancer detected on PAP smear A 60 year old woman with a history of breast cancer was referred after malignant cells were found on PAP smear. Abdominal exam, cervical visualisation, transvaginal ultrasound and CT of the abdomen and pelvis were all normal. Endocervical and endometrial curettings demonstrated serous carcinoma cells consistent with tubal / ovarian origin. CA125 was slightly elevated at 53 (Upper Limit of Normal 35). At laparatomy uterus, fallopian tubes and ovaries appeared normal. She had a hysterectomy, bilateral salpingo-oophorectomy, omentectomy, peritoneal biopsies and washings. There was no macroscopic evidence of cancer, but microscopic examination confirmed serous cancer in the fimbrial end of the left fallopian tube(A) with scattered malignant cells in the lumen of both fallopian tubes(B), the omentum(C) and surface of the ovaries(D), surface of uterus and paracolic gutter. Washings were positive. Family history was unremarkable. BRCA mutation screening revealed a BRCA1 mutation. Despite intraperitoneal cisplatin and paclitaxel she relapsed and died 4 years later.
Highlights
From Familial Aspects of Cancer 2011 Research and Practice: A combined meeting of kConFab, Australian Breast Cancer Family Study, Australian Colorectal Cancer Family Study, Australian Ovarian Cancer Study, Family Cancer Clinics of Australia and New Zealand and kConFab Kingscliff, Australia. 23-26 August 2011
Case 1: Serous tubal cancer detected on PAP smear A 60 year old woman with a history of breast cancer was referred after malignant cells were found on PAP smear
There was no macroscopic evidence of cancer, but microscopic examination confirmed serous cancer in the fimbrial end of the left fallopian tube(A) with scattered malignant cells in the lumen of both fallopian tubes(B), the omentum(C) and surface of the ovaries(D), surface of uterus and paracolic gutter
Summary
From Familial Aspects of Cancer 2011 Research and Practice: A combined meeting of kConFab, Australian Breast Cancer Family Study, Australian Colorectal Cancer Family Study, Australian Ovarian Cancer Study, Family Cancer Clinics of Australia and New Zealand and kConFab Kingscliff, Australia. 23-26 August 2011. Case 1: Serous tubal cancer detected on PAP smear A 60 year old woman with a history of breast cancer was referred after malignant cells were found on PAP smear. Cervical visualisation, transvaginal ultrasound and CT of the abdomen and pelvis were all normal.
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