Pathological diagnosis of non-Hodgkin lymphoma

Abstract

The clinicopathological characteristics and diagnosis of non-Hodgkin lymphoma were analyzed, including (1) clinical manifestations: lymph nodes are enlarged with B symptoms including extension and fever; (2) histopathology: dysplasia and clonal proliferation of tumor cells, invasion and destruction of normal tissue structure are noted; (3) immunophenotype: it shows an immunophenotype consistent with histopathology; (4) molecular pathology: molecular pathological tests are performed when morphological and immunohistochemical findings cannot determine benign or malignant lesions. Ig and T cell receptor polymerase chain reaction gene rearrangements detection is commonly used to determine the clonality. When the results of above four aspects are the same, lymphoma can be diagnosed, and if there is any doubt, the diagnosis of lymphoma cannot be made. Key words: Lymphoma, non-Hodgkin; Pathological diagnosis