Pathological changes in adrenal cortex of mouse during experimental meningococcal infection.

Abstract

SummaryEmploying a technic which minimized the production of artifacts, a histological study was made of the adrenal glands of mice infected with meningococcus and also of appropriate controls. Depletion of fat, engorgement and inflammatory cell infiltration were demonstrated during the course of the infection. After successful treatment with penicillin the adrenal cortex showed a progressive recovery as manifested by reaccumulation of fat and reduction of hyperemia and inflammatory reaction.