Abstract
Sickle Cell Disorder (SCD) is a congenital hemoglobinopathy. There is little in literature regarding the psychological variables affecting individuals living with SCD and all of the significant people around them. There are also limited numbers of trained clinical psychologists and genetic counselors to cater for the psychotherapeutic needs of individuals living with SCD. Even among those who have been trained, only a few might have fully grasped the complexities of the disease pathology.Early understanding of its pathological nature, sources, types, complications, pathophysiological basis, and clinical severity of symptoms among clinical psychologists, genetic counselors and psychotherapists, as well as general medical practitioners, could guide them in providing holistic care for dealing with and reducing pain among individuals living with SCD. It could allow risk-based counseling for families and individuals. It could also justify the early use of disease-modifying or curative interventions, such as hydroxyurea (HU), chronic transfusions (CTs), or stem-cell transplantation (SCT) by general medical practitioners. Hence, the need for this paper on the pathophysiology of SCD.
Highlights
Dr Ilesanmi Oluwatoyin Olatundun, Clinical Psychologist, PN & M, Trained Genetic Counselor, is concerned with taking care of people with the sickle cell disorder, to create awareness about the prevention and control of sickle cell disorder, blood group Rhesus factor, malaria control in sickle cell disease, research and raising aware
There is little in literature resistant to malaria, since the infestation of regarding the psychological variables affecting the malaria plasmodium is halted by the sickness on human immunodeficiency virus (HIV)/AIDS in Nigeria and beyond, through information, psychoeducation and communication, screening and genetic counseling
Non Introduction affects around 72,000 people, most of whose ancestors come from Africa.[6]
Summary
Pathophysiological mechanisms precipitating sickle cell disorder crisis tion was central to the development of its Current treatment and understanding of SCD symptoms. In 1917, Emmel noted that the degree of erythrocyte deformation varied with °Sicklecell.md require an appreciation of the complexity of its basic pathophysiology. These are the complex time[9] and Hahn and Gillespie[7] demonstrated *Sicklecell.md FAQ: "Why is Sickle Cell mechanisms by which abnormal hemoglobin that this eponymous change was induced by Anaemia only found in Black people?. Article effects of SCD.[10,11] These include the sickling Table 1. Polymerization of deoxy-Hb.[14] process, hemoglobin cyclic polymerization, the Sickling-unsickling
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