Abstract
Mammary gland cancer is the most common cancer occurring in women globally. Incidences of this cancer in Japan are on the increase. Annually, more than 70,000 new cases are recorded in Japan and about 1.7 million in the world. Many cases are still difficult to cure completely, and animal models are required for the characterization of the biology, therapeutic strategy, and preventive measures for spontaneous mammary tumor. The mouse model used currently has some limitations owing to structural differences between mouse and human mammary glands. Tupaia belangeri (tree shrew), which belongs to the Tupaiidae family, shows relatively high genetic homology and structural similarity to human mammary glands. Here, we characterized the spontaneous mammary tumors in 61 female tree shrews of different ages. The incidence rate was 24.6% (15/61), and the rate of simultaneous or metachronous multiplex tumors was 60% (9/15). From the incidence pattern, some cases seemed to be of familial mammary gland tumor, as the offspring of female tree shrews No. 3 and 9 and male tree shrew No. 11 showed a high incidence rate, of 73.3% (11/15). Average incidence age for tumor development was 2 years and 3 months, and the earliest was 10 months. Histochemical analysis indicated that spontaneous mammary gland tumors in the tree shrew show the features of intraductal papillary adenomas (22 cases), except 2 tubulopapillary carcinoma cases (No. 75 and 131). All the cases were positive for the progesterone receptor, whereas 91.3% were positive for the estrogen receptor, and 4.3% were HER-2 positive. We have also confirmed the expression of nectin-4 in some mammary tumor cells. Additionally, we subjected tree shrews to cytodiagnosis or X-ray CT. Thus, the findings of this study highlight the potential of the tree shrew as a valuable new animal model for mammary gland tumor study.
Highlights
Mammary gland cancer is among the most prevalent forms of cancer in women [1]
Rodents are used in most of the studies associated with breast cancers [3], they are different from human beings in terms of both the biological characteristics and molecular mechanisms underlying development and progression of breast cancers, which limit their application in breast cancer research
The results in this study showed that tree shrews can develop spontaneous mammary tumors
Summary
Mammary gland cancer is among the most prevalent forms of cancer in women [1]. In Japan, more than 70,000 women are diagnosed of mammary gland cancer every year [2].not all the patients can be cured at present. Mammary gland cancer is among the most prevalent forms of cancer in women [1]. In Japan, more than 70,000 women are diagnosed of mammary gland cancer every year [2]. Rodents are used in most of the studies associated with breast cancers [3], they are different from human beings in terms of both the biological characteristics and molecular mechanisms underlying development and progression of breast cancers, which limit their application in breast cancer research. The genome sequence of tree shrew shows a higher homology with that of primates [4,5,6]. The development and physiological characters of the tree shrew’s mammary gland are similar to those of human beings [12, 13]
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