Abstract
A study to elucidate the effects of atomic bomb (A-bomb) radiation exposure on the incidence of stomach cancer was conducted on 79, 856 A-bomb survivors included in the Life Span Study sample for whom dose estimates are available. From cases diagnosed during the period 1950-77 a total of 2, 155 were accepted, following review of the clinical and pathologic records, as meeting the criteria for stomach cancer. 1. Evaluation of the effects of each dose group corrected for sex and age, showed a significant increase in the risk of stomach cancer only in the heavily exposed 200+ rad group. In the 200+ rad group, the increase in stomach cancer risk was remarkable in the under 30 years of age at the time of the bomb (ATB) group. 2. The dose-response relationship of the incidence of stomach cancer as followed over a period of 27 years is not quadratic, but linear. Based on this finding, the estimated risk of A-bomb radiation-induced stomach cancer is 1.24 per 1 million person years/rad. 3. Histologically, the differentiated type is frequently observed in the control and low dose groups, and poorly differentiated type in the high dose group. 4. There is a significant difference between these histological types in the degree of intestinal epithelial metaplasia by exposure dose.
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