Abstract
Undifferentiated colorectal carcinoma with rhabdoid features is unusual, aggressive, and resistant to chemotherapy. Compared to rhabdoid phenotype, immunohistochemistry is a more reliable way of detecting undifferentiated colorectal carcinoma with rhabdoid features. An increasing number of studies have reported that defects in core subunits of the switch/sucrose-nonfermenting complex may play an important role in the formation of rhabdoid tumors. Herein, we report the first case, to the best of our knowledge, with a pathologic complete response after neoadjuvant chemotherapy. A 65-year-old Taiwanese female had carcinoma over the ascending colon and multiple metastases to mesenteric lymph nodes and peritoneum. The immunohistochemical findings resembled those of rhabdoid features. She had received neoadjuvant chemotherapy with bevacizumab plus irinotecan with leucovorin and 5-fluorouracil (modified FOLFIRI). Follow-up computed tomography and surgical specimens revealed a favorable outcome. The effectiveness of neoadjuvant multiagent therapy for this rare carcinoma may inspire future research of tumorigenesis and novel treatments.
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