Abstract
Objective:To investigate the pathologic characteristics and differential diagnosis of pancreatic cancer among residents in Shanghai urban area.Methods:A population-based large case-control study was performed in patients with pancreatic cancer between December 2006 and January 2011 in Shanghai urban area.The pathologic slides from 387 cases of pancreatic cancer were collected and reviewed by five experienced pathologists.The pathologic diagnosis was determined according to WHO Classification of Tumors of the Digestive System,Fourth Edition(2010).Results:Three hundred and fifty cases(90.4%) were confirmed as pancreatic cancer.Most of the pathologic slides were obtained from resected tissues of pancreatic cancer(311/350,88.9%).The average diameter of the tumor was 4 cm,and 56.6%(n = 198) of the tumors were located in the head of pancreas.The ductal adenocarcinoma was the most common histologic subtype(n = 311,89.0%),followed by pancreatic neuroendocrine tumors(n = 15,4.3%).The most common histologic grades were Ⅱ/Ⅲ(n = 252).According to TNM staging system,40 cases had stage ⅠA,209 cases had stages ⅠB/ⅡA,and 80 cases had stage ⅡB.The perineural invasion was identified in 175 cases,and the lymphovascular and/or venous emboli were identified in 56 cases.Only one case was misdiagnosed.Conclusion:The understanding of pathology of pancreatic cancer in Shanghai urban area was improved through this pathologic review.
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