Pathologic Changes in Pigeons Infected with a Virulent Trichomonas gallinae Strain (Eiberg)

Abstract

Trichomonas gallinae, Eiberg strain, is a virulent hepatotropic flagellate parasite of pigeons. The parasite initially infects the upper digestive tract, causing the formation of ulcers, which allow it to enter the circulatory system. The trichomonads later gain access to the liver, where they cause the formation of caseous lesions. Vascular congestion and perivascular cuffing in the liver were seen as early as 4 days postinfection (PI). By day 7 PI, a marked reduction in abdominal fat and hepatosplenomegaly was evident. Hepatocytes underwent fatty degeneration (seen by day 7 PI) before total necrosis set in. On day 8 PI, trichomonads could be found among the necrotic hepatocytes in caseous lesions. These lesions were delineated by a wall of leukocytes and occasional giant cells. Nonimmune pigeons died within 14 to 17 days PI of liver dysfunction. Other organs (kidney and genitalia) were also seen to undergo degeneration. These manifestations probably reflect the progression of liver dysfunction.