Abstract
Male Wistar rats were exposed to bituminous coal dust considered to have high potential for induction of coal workers' pneumoconiosis (CWP). They developed lesions similar to simple CWP as described in human subjects. Comparable lesions observed were macules (focal, coal-laden macrophage accumulations associated with increased interstitial reticulin and collagen, with emphysema involving alveoli within the macule), which were of increased size, altered shape, and increased density in animals experiencing chronic exposures. More advanced lesion types, i.e., micronodule, macronodule, silicotic nodule, Caplan's lesion, and infective granuloma, were not observed in the experimental animals. Focal bronchiolization occurred in animals receiving at least 20 months' exposure. In the literature reviewed, this pathologic change is not described as a component of CWP.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
