Abstract
Sheep diseases of invasive and non-invasive etiology are among the restrictive factors for Ukrainian sheep-breeding. The helminthiases are among the most widespread parasitical diseases, and particularly strongyloidiasis causes significant losses for sheep farms in cases of severe course. Young sheep are the most susceptible, showing growth and developmental lag, and death occurs in cases of high invasiveness due to severe pathologies induced by the parasites. Thus the aim of the present work was to study the morphological and histological changes in the intestine, lungs and liver of sheep with strongyloidiasis. Results of pathoanatomy showed that under spontaneous sheep strongyloidiasis with the intensity of the invasion from 50 to 136 specimens of nematodes, the main pathological changes occur at Strongyloides localization sites: intestine and parenchymatous organs (lungs and liver). Particularly, the small intestine showed catarrhal desquamative enteritis. Morphological changes of its mucosa demonstrated necrosis of the apical part of the villi, desquamation of epithelium, constriction and decrease of intestinal crypts. At the same time, massive diffusive cell infiltrates were detected in the intestinal mucosa lamina propria with the prevalence of eosinophilic leukocytes, inflammatory thickening of villi cylindrical epithelium and its mucous metamorphosis, pyknosis and lysis of enterocyte nuclei. In the large intestine, necrosis of the mucosa was detected, with edema, effusion of serum-cell exudate in its canal, diffusive infiltration of lymphocytes, eosinophils and plasma cells in the intestinal mucosa lamina propria. Lung tissue demonstrated parasite larvae localized in canals of the bronchi and in alveoli. These sites had diffusive hemorrhages in lung parenchyma, signs of inflammation and thickening of interstitial tissue caused by damage to vessel walls due to migration of parasite larvae. Histological changes in the liver of sheep with strongyloidiasis showed the development of granular dystrophy and necrotic changes in hepatocytes.
Highlights
For modern farming, restoration and development of sheep-breeding may be promising in terms of increasing effective land use, population employment rate and supply of the national sector of meat processing and light industry with raw material with curative properties (Banerjee et al, 2009; Anteneh & Yadav, 2017)
Under conditions of severe experimental S. papillosus invasion of goats, approximately 6% of animals died due to anemia caused by liver damage
We showed that with S. papillosus invasion at intensity of from 50 to 136 specimens of nematodes, pathological changes develop in the organisms of sick sheep in the parasites’ locality, but in the liver and lungs as well
Summary
Restoration and development of sheep-breeding may be promising in terms of increasing effective land use, population employment rate and supply of the national sector of meat processing and light industry with raw material with curative properties (Banerjee et al, 2009; Anteneh & Yadav, 2017). One of factors that decreases the efficacy of sheep-breeding development and causes economic losses is helminthiases, strongyloidiasis caused by Strongyloides papillosus (Dimitrijevic et al, 2016; Boyko & Brygadyrenko, 2017, 2019a, 2019b; Boyko et al, 2009, 2020). Scientists stated that with experimental invasion by S. papillosus larvae, they were detected in the lungs, trachea and esophagus already in 90 hours, which indicates their fast migration via the bloodstream (Nwaorgu & Connan, 1980). Other scientists found larvae in the myocardium and mammary glands along with hemorrhagic inflammation of intestinal mucosa during pathoanatomical dissection of sheep, experimentally infected by S. papillosus. Pathological changes were absent in other organs (Turner, 1959; Nwosu et al, 2007)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
