Abstract
The development of tumours implies a disproportion between proliferation, growth and differentiation, which is accompanied by significant genotypic and phenotypic variations in the diseased. The scenario of multiple oncogenic effects on the inhibition of cell growth, apoptosis and maturation, on the stimulation of proliferation, on cell migration and tissue invasion, is responsible for the occurrence of tumours both in humans and in animals. The qualitative and quantitative determination of biological prognostic factors in the tissue of affected cats and dogs directly indicates a possible tumour metastasizing, and consequently also the prognosis of neoplastic disease. Monitoring of clinical and biological prognostic factors is important for therapy and prediction of tumours in humans and animals. The determination of the proliferative potential of tumour cells by immunohistochemical detection of Ki-67 and PCNA is used in grading certain tumours in cats and dogs. It is also possible immunohistochemically to prove factors of angiogenesis and numerous activating and inhibiting proteins in the tumour tissue. In addition to other histological, clinical and biological parameters, they are significant for the further prognosis and therapy of neoplastic diseases.
Highlights
Normalna tkiva u procesu obnavljanja i rasta ispoljavaju ravnotežu između ćelijske proliferacije, diferencijacije i programirane ćelijske smrti
kliničke i biološke parametre značajni za dalju prognozu i terapiju neoplastičnih bolesti
Vet. glasnik 69 [3,4] 245 - 254 (2015) Aleksić-Kovačević Sanja i sar.: Patohistološki i imunohistohemijski parametri značajni za prognozu i terapiju tumora pasa i mačaka ljudi dokazano da ekspresija Ki-67 ima prediktivan značaj za reakciju tumora na hemioterapiju
Summary
Normalna tkiva u procesu obnavljanja i rasta ispoljavaju ravnotežu između ćelijske proliferacije, diferencijacije i programirane ćelijske smrti. Vet. glasnik 69 [3,4] 245 - 254 (2015) Aleksić-Kovačević Sanja i sar.: Patohistološki i imunohistohemijski parametri značajni za prognozu i terapiju tumora pasa i mačaka je za nastanak tumora kod ljudi i životinja.
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