Abstract
Objective To explore pathogens causing bacterial pneumonia in children and drug resistance in hospital, and supply evidence on diagnosis and therapy of a clinical basis. Methods From January 2009 to December 2010, a total of 892 children with bacterial pneumonia were involved in this study. All subjects were investigation by Questionnaire of Bacterial Pneumonia in Children and sample were collected. Antimicrobial susceptibility of antibiotics was detected by Kirby-Bauer method. Producing extended spectrum β-lactamases (ESBLs) bacteria were identified by double-disk synergy test. The procedure of this study was consistent with ethical standard established by the committee of investigation in human beings of Obstetrics and Gynecology Hospital of Hainan Province. And it was approved by this committee. Guardians or patients were informed of grouping and their written informed consent was obtained before clinical studies. Results A total of 155 pathogenic bacteria strains were isolated from 135 children, and isolation rate was 15.13%. The top five bacterial strains were Klebsiella pneumoniae, Escherichia coli, Streptococcus pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa, which accounted for 22.58%, 17.42%, 14.84%, 13.00% and 10.97% of the total bacteria strains, respectively. Drug resistance rates of Klebsiella pneumoniae, Escherichia coli, Streptococcus pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa were much more than 80% to penicillin, while much more than 77.0% to Ampicillin and amoxicillin. Drug resistance rate in 2010 was much more than that in 2009. A total of 40 producing ESBLs bacteria strains were identified by double-disk synergy test among tep five bacterial with the detection rate of 32.79%. Conclusions All of the bacterial pneumonia in children have the drug resistant feature, and producing ESBLs bacteria are at prevalence to a certain extent. Key words: bacterial pneumonia; pathogen; drug resistance; child
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