Abstract

目的 探讨我院新生儿败血症的病原菌分布及耐药性,指导临床合理使用抗生素.方法 对我院2004年12月~2008年3月新生儿血培养阳性标本细菌鉴定及药敏结果进行分析总结.结果 98例101次血培养阳性标本中,革兰阳性球菌95例占94.1%,革兰阴性菌6例占5.9%;革兰阳性球菌中松鼠葡萄球菌35例占34.7%,表皮葡萄球菌23例占22.8%,模仿葡萄球菌21例占20.8%,均对多种抗生素耐药,对青霉素全部耐药,对氨苄西林/舒巴坦,红霉素耐药率70%以上,对万古霉素100%敏感;分离的革兰阴性菌有大肠埃希菌2例、阴沟肠杆菌1例、坂崎肠杆菌1例、干燥棒状杆菌1例、铜绿假单胞菌1例,抗菌活性较好的药物是亚安培南,第三代头孢、哌拉西林/他唑巴坦等.结论 葡萄球菌是新生儿败血症的主要病原菌,对常用抗菌药物有不同程度的耐药.全面了解和掌握细菌种类和耐药性变化对临床合理选用抗生素具有重要意义。

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