Abstract
Since Anderson, et al.,1 described 3 types of C. diphtheria, the relative virulence of these organisms for common laboratory animals has been the subject of much study. Povitsky, Eisner, and Jackson2 observed that it took 4 times smaller dose of grams than mitis types to kill guinea pigs. Murray3 showed that in virulence for rabbits, the order was gravis, intermediate, mitis. Gundel and Ezrin4 found that the organisms of the gravis type were not only more virulent than those of intermediate and mitis types, but definitely more invasive in guinea pigs. However, Parish and his coworkers5 could demonstrate no such high virulence of the gravis type either in rabbits or in guinea pigs. In view of such conflicting reports, a further study of this problem in another species of laboratory animal seems to be desirable. As the Chinese hamsters have been found to be highly susceptible to C. diphtheria infection, and since they can be easily procured in large numbers and at low cost,6 these animals have been chosen f...
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