Abstract
Globozoospermia is a rare (0.1%) but severe disorder in male infertility, with round-headed and acrosomeless sperm defects. The pathogenesis of globozoospermia most probably originates in spermiogenesis, more specifically in acrosome formation and sperm head elongation. It is confirmed with genetic origin. Five human genes and 17 mice genes have been so far confirmed in presenting globozoospermia. Intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA) has been proved to be a very efficient fertilization technique when compared with conventional ICSI in globozoospermia. In this paper, the discovery, recognition and definition of round head sperm, morphological characteristics and ultrastructure, related genes and pathogenesis, and the outcome of assisted reproduction in globozoospermic patients were summarized and discussed. Key words: Globozoospermia; Teratozoospermia; Genetic mutation; Reproductive techniques, assisted; Male infertility
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