Abstract
Urinary tract infection (UTI) during pregnancy is often correlated with complications. As the main objective of this study, we investigated the prevalence of antimicrobial susceptibility, resistance genes, virulence genes and its relationship with different phylogenetic groups among Uropathogenic E. coli strains isolated from pregnant women with asymptomatic bacteriuria who referred to Hafez hospital, Shiraz, Iran. Our results revealed that among 300 urine samples, 105 (35%) were positive for E. coli. The data demonstrated that the highest and the lowest resistance rates were observed against nalidixic acid (82.1%), and imipenem (2.8%), respectively. The frequency of ESBLs and AmpC-β-lactamase, in the Uropathogenic E. coli isolates was 41% and 9.5% respectively. blaCTXM was the commonest genotype (93%). Phylogenetic group distribution was as follow: B1 2.8%, A 14.2%, B2 61.9% and D 4.6%. Our result showed that most of the virulence genes belonged to group B2 and also several virulence genes such as hlyA, cnf-1 and papGII genes were positively associated with group B2. Among E. coli strains isolated from patients with UTIs, different features phylogroups, with special virulence factors, could cause severe infection. Awareness about the virulence patterns distribution among phylogenetic groups of UPEC could greatly aid in confine and prevent the development of lethal infection caused by these strains.
Highlights
Asymptomatic bacteriuria is one of the common problems in pregnancy
An observational crosssectional study including investigated the prevalence of virulence genes, antimicrobial resistance, and its relationship with phylogenetic groups among E. coli strains isolated from pregnant women with asymptomatic bacteriuria who referred to Hafez hospital, Shiraz, Iran
E. coli ability to colonize various sites is due in part to genome specific characteristics by acquisition or loss of genes encoding virulence factors and antibiotic resistance genes[5].The interaction between Uropathogenic Escherichia coli (UPEC) and epithelial cells is effected by several factors and complex phenomenon, involving various adhesins produced according to the stage of infection while its adherence to epithelial cells plays a critical role for a successful colonization and establishment
Summary
Asymptomatic bacteriuria is one of the common problems in pregnancy. Pyelonephritis, preterm labor and low birth weight infants have been associated with bacterial infection. Urinary tract infection (UTI) during pregnancy is frequently associated with complications. An observational crosssectional study including investigated the prevalence of virulence genes, antimicrobial resistance, and its relationship with phylogenetic groups among E. coli strains isolated from pregnant women with asymptomatic bacteriuria who referred to Hafez hospital, Shiraz, Iran. Pregnant women are typically screened for urinary tract infections (UTIs) in early pregnancy and those with bacteriuria are treated with antibiotics[1]. There are few studies on virulence factor genes (VFGs), antimicrobial resistance and pattern of phylogenetic groups amongst the E. coli isolated from asymptomatic pregnant women in Iran. The objective of our study was to investigate the prevalence of virulence genes, antimicrobial resistance, and its relationship with phylogenetic groups among E. coli strains isolated from asymptomatic pregnant women who referred to Hafez hospital, Shiraz, Iran
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