Abstract
This paper attempts to analyze the related factors of cervical cancer combined with immunotherapy, taking cervical cancer patients as the experimental object, through the establishment of cervical cancer model, combined with natural immune agonists, immune activated monoclonal antibody and HPV polypeptide to explore its prevention or treatment of cervical cancer immune research.The results showed that the number of people with bad habits was more, and the incidence rate of cervical cancer was relatively high. However, for those without formal work, the number of cases of bad sexual behavior is more, and HPV transmission is easier, which also provides convenience for the occurrence of cervical cancer. The mechanism of action of tumor therapeutic vaccine is different from that of cytotoxic drugs. Its particularity lies in that the induction of specific anti-tumor immune response needs a certain period of time before it can be transformed into clinical effect; and patients with recurrence or metastasis usually receive multiple rounds of treatment, which may affect the immune system and reduce the efficacy of the vaccine.
Highlights
Cervical cancer is the most common malignancy in female genital tract
Yang found that two cervical cancer cell lines HeLa and SiHa did not respond to the cytotoxicity of TNF - α
The cytotoxicity to TNF - α of sensitized cells by blocking mir-130b function or overexpression of PTEN gene.Yang's experiment showed that mir-130b inhibited PTEN gene expression by directly binding with 3'UTR of PTEN mRNA
Summary
Cervical cancer is the most common malignancy in female genital tract. Due to the popularity of cervical cytology screening, the improvement of social and economic level and the change of lifestyle, the incidence rate and mortality rate of cervical cancer in most developed countries showed a downward trend. The cytotoxicity to TNF - α of sensitized cells by blocking mir-130b function or overexpression of PTEN gene.Yang's experiment showed that mir-130b inhibited PTEN gene expression by directly binding with 3'UTR of PTEN mRNA. These data suggest that mir-130b expression is a target of inhibition, which makes tumor cells more sensitive to the toxic effects of TNF - α [4,5]. We followed the domestic and foreign research on cervical cancer immunology, and further explored the latest achievements of immunotherapy and prevention on the basis of understanding the pathogenic factors and pathogenesis of cervical cancer. This paper analyzes the correlation between tigit and T cell specific immune response in cervical cancer, which can provide clues for immunotherapy of cervical cancer
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