Abstract
Multiregional outbreaks of meningitis-like disease caused by Elizabethkingia miricola were confirmed in black-spotted frog farms in China in 2016. Whole-genome sequencing revealed that this amphibian E. miricola strain is closely related to human clinical isolates. Our findings indicate that E. miricola can be epizootic and may pose a threat to humans.
Highlights
Multiregional outbreaks of meningitis-like disease caused by Elizabethkingia miricola were confirmed in blackspotted frog farms in China in 2016
We identified E. miricola as the predominant pathogen and used whole-genome sequencing (WGS) to further characterize this Asian epizootic isolate and phylogenetically compare it with the available typical Elizabethkingia genomes
The results showed that FL160902 was most closely related to CSID_3000517120, a clinical isolate of E. miricola from the United States sequenced by the Centers for Disease Control and Prevention (CDC) [10], revealing the potential of E. miricola FL160902 for pathogenicity in humans
Summary
Multiregional outbreaks of meningitis-like disease caused by Elizabethkingia miricola were confirmed in blackspotted frog farms in China in 2016. We identified E. miricola as the predominant pathogen and used whole-genome sequencing (WGS) to further characterize this Asian epizootic isolate and phylogenetically compare it with the available typical Elizabethkingia genomes. The Study Since May 2016, many black-spotted frogs in farms in Hunan Province in south-central China have experienced an emerging, contagious disease characterized mainly by severe neurologic dysfunction.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
