Pathogenic bacteria distribution and drug resistance in primary hospital from 2011 to 2013

Abstract

Objective To explore the distribution and drug-resistant conditions of pathogens isolated from the patients in primary hospital,so as to provide the basis for rational use of antibiotics.Methods Pathogen species isolated from Tiantai Traditional Chinese Medical Hospital of Zhejiang province from January 2011 to December 2013 were analyzed to understand the isolate distribution and drug resistance.Results A total of 896 clinical isolates were collected.The gram-negative bacteria accounted for 58.6％,including Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa and Acinetobacter baumannii.The gram-positive bacteria accounted for 31.6％,including Staphylococcus aureus,Coagulase negative staphylococcus,Enterococcus faecalis and Enterococcus faecium.The fungi accounted for 9.8％,including Candida albicans and Candida tropicalis.The number of clinical isolates increased in three years.Drug resistance analysis showed that gram-negative bacteria were resistant to many common antibiotics,with resistant rates over 80.0％ in some strains.The gram-positive bacteria were sensitive to vancomycin,tigecycline and teicoplanin,but the resistant rates were over 60.0％ in the rest of commonly used antibiotics.In the fungi,Candida albicans,Candida tropicalis and Candida glabrata were sensitive to 5-fluorocytosine and amphotericin B,but Candida tropicalis had a higher resistant rate to fluconazole and itraconazole.Conclusions Pathogens in primary hospital has a wide distribution,and the isolation rate increases year by year with a serious drug resistance condition.It shows that the prevalence of pathogen resistance spreads to local hospital. Key words: Bacterial infections ; Drug resistance ; Primary hospital