Pathogenic bacteria cultivating by bile from patients with malignant obstructive jaundice and drug resistance analysis

Abstract

Objective To analysis the distribution of main pathogenic bacteria cultivating by bile from malignant obstructive jaundice patients and their sensitivity to antibiotics so as to provide evidence for clinical reasonably use of antibiotics. Methods A total of 455 cases of malignant obstructive jaundice patients´ results of the bacterial culture of bile and the drug susceptibility testing were retrospectively analyzed. Results There are 116 patients had a positive bile culture in 455 patients, the positive rate was 25.5%. Totally 147 strains were identified including 118 gram negative strains (80.3%,118/147) and 24 gram positive strains (16.3%, 24/147), 5 fungal strains (3.4%, 5/147). The drug resistance rates of gram negative strains to imipenem and meropenem were the lowest, followed by amikacin, cefoperazone and sulbactam; the drug resistance rates of gram negative strains to linezolid and vancomycin were the lowest. Of 118 gram negative strains,30 strains (25.4%) were ESBLs producers. Conclusions Malignant obstructive jaundice patients´ results of the bacterial culture of bile were mainly gram negative strains. The antimicrobial resistance of pathogens was increasingly serious. So we should seasonably use of antibiotics according to the drug susceptibility to raise the clinical healing rate of biliary tract infection. Key words: Jaundice, obstructive; Bile bacterial culture; Resistance