Pathogenic bacteria and drug resistance analysis of 72 cases of premature infants with nosocomial fungal infection

Abstract

Objective To understand the distribution of pathogen and antibiotic resistance of nosocomial fungal infection,and provide evidence for the prevention of fungal infection in premature infants in hospital.Methods The clinical data of 72 cases of premature infants with nosocomial fungal infections were retrospectively analyzed.Results The top three of the pathogenic of fungal infection in premature infants in our hospital were 38 strains of Candida pelliculosa (52.8％,38/72),10 strains of Candida albicans (13.9％,10/72),9 strains of Candida parapsilosis (12.5％,9/72).The weights of 72 cases with nosocomial fungal infection in preterm infants were below 2000 g,who were dominated by very low birth weight infants.Gestational age of 27 ～ 30 weeks were in the majority,which accounted for 36.1％ of 27 ～ 28 weeks (26/72) and 34.7％ of 29 ～30 weeks (25/72),each group were dominated by bacteria pathogen candida.Seventy-two strains of fungi were isolated to amphotericin B drug resistance,the 1.4％ (1/72) resistance rate to fluconazole,4.2％ (3/72) pairs of voriconazole resistance rate,2.8％ (2/72) for itraconazole resistant rate.There were no significant differences among the last three resistant rate (x2 =1.02,P ＞ 0.05).The 5-fluorine cytosine resistance accounted for 59.7％ (43/72),and the 4 kinds of drug resistance rate had significant difference (x2 =57.73,P ＜ 0.05).There was no significant difference in resistance rate between amphotericin B and fluconazole (x2 =1.01,P ＞ 0.05).Conclusion Fluconazole could be used to those premature infants with high risk factors of fungal infection.Once the fungal infection is diagnosed,intravenous fluconazole could be the first choice,when necessary,amphotericin B can be used together. Key words: Nosocomial infection; Fungi; Drug resistance; Premature infant