Abstract
The emergence of Pseudomonas aeruginosa as a potential threat in persistent infections can be attributed to the plethora of virulence factors expressed by it. This review discusses the various virulence factors that help this pathogen to establish an infection and regulatory systems controlling these virulence factors. Cell-associated virulence factors such as flagella, type IV piliand non-pilus adhesins have been reviewed. Extracellular virulence factors have alsobeen explained. Quorum-sensing systems present in P. aeruginosa play acardinal role in regulating theexpression of virulence factors. The identification of novel virulence factors in hypervirulent strains indicate that the expression of virulence is dynamic and constantly evolving. An understanding of this is critical for thebetter clinical management of infections.
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