Abstract
The dynamics of the indices of fibrinolysis and cellular adhesion in patients with chronic diffuse liver diseases and euthyroid syndrome against the ground of administration of selenium-containing drugs, has been studied. The administration of selenium-containing drugs in a comprehensive therapy of patients with chronic diffuse liver diseases with disorders of thyroid homeostasis was found to improve the indices of the blood plasma fibrinolytic system, to reduce adhesive cellular properties and to increase total enzymatic activity of the blood plasma.
Highlights
Disorders of the endothelial participation in the regulation of fibrinolysis are an important link in pathogenesis of many diseases including chronic diffuse liver diseases (CDLD) [1, 2, 4]
Disorders of the local fibrinolysis are an important factor in the development and progressing of CDLD which can be caused by disorders of the liver circulation, and results in an increased release of thromboplastin, a powerful triggering factor of blood clotting, into the blood [5, 6]
Indicators studies of thyroid homeostasis at patients with CDLD established a probable reduction in fТ3 and increase of the concentration in fТ due to failure of peripheral monodeiodization against the increasing of thyroid stimulating pituitary function
Summary
Disorders of the endothelial participation in the regulation of fibrinolysis are an important link in pathogenesis of many diseases including chronic diffuse liver diseases (CDLD) [1, 2, 4]. Disorders of the local fibrinolysis are an important factor in the development and progressing of CDLD which can be caused by disorders of the liver circulation, and results in an increased release of thromboplastin, a powerful triggering factor of blood clotting, into the blood [5, 6]. Endothelial dysfunction causes occurring and progressing of thyroid homeostasis disorders [3], which is indicative of the necessity to elaborate effective methods of its correction
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