PATHOGENETIC SUBSTANTIATION OF CORRECTION OF IRON CONTENT IN WOMEN'S BLOOD ON THE STAGE OF PRECONCEPTIONAL PREPARATION FOR PREGNANCY

Abstract

The aim of the study was to prove the effectiveness of preventing the occurrence of obstetric and perinatal complications by using personalized preventive measures for correcting the content of iron and substances that affect its metabolism, ferritin, cyanocobalomin, folic acid in a woman's body at the stage of preparation for pregnancy and by trimesters of gestation.Materials and research methods. 90 women of reproductive age were examined at the stage of preconception preparation and pregnancy. The content of iron, ferritin, folic acid, cyanocobalamin, alleles of the folate cycle enzyme genes in the blood of women before and during pregnancy was determined. A pathogenetically substantiated personified algorithm for the prevention of obstetric-perinatal complications through the use of nutritional therapy, ferrous iron preparations, and vitamin complexes containing metafoline is proposed.Research results and their discussion. The frequency of polymorphic alleles of the folate cycle enzyme genes was more than 70% in women of both groups and there was no significant difference between the groups of subjects examined for homo-, heterozygous alleles. According to the trimesters of pregnancy, the content of iron and substances that affect its metabolism, ferritin, folic acid, cyanocobalamin in women who underwent preconception training (group I) in relation to group II (comparison) was significantly higher (p < 0.001). A decrease in the level of ferritin in the blood of women of group II corresponded to a decrease in the level of iron, folic acid, and cyanocobalamin. In women who underwent the proposed preparation for pregnancy and preventive and therapeutic measures during the gestational periods, the frequency and severity of anemia in pregnant women and other gestational complications was significantly lower than in the comparison group during three trimesters and the early postpartum period (p < 0, 05).Conclusions. The results of the studies carried out confirm the effectiveness of the complex (nutritional and medication) step-by-step personalized correction of the content of iron and substances (ferritin, folic acid, cyanocobalamin) that affect its metabolism and the process of tissue respiration, at the stage of pre-conceptual preparation 3-4 months before fertilization and by trimesters of gestation. The proposed algorithm of examination and prophylactic - therapeutic measures is a pathogenetically substantiated method for preventing obstetric-perinatal complications