Abstract
Taking into account the importance of platelets in the mechanisms of inflammation and the autoimmune process, the aim of this study was to experimentally answer a simple question: whether platelets in people with autoimmune euthyroidism, hyperthyroidism and hypothyroidism exhibit the characteristics of high activity. The study included 35 patients with autoimmune thyroid gland disease, positive for both TRO-Ab and Tg-Ab, and with elevated TTH, and 50 patients with elevated T4 and / or T3 concentrations and depressed levels of TTH, presence of TSHR antibodies, and / or anti-microsomal antibodies. As a result of this study, it was found that ADP-induced aggregation, that is, its parameters depend on the concentration of the aggregation inductor. According to the results of our study, we hypothesized that PMPs can interact with circulating autoantibodies and C1q involved in the formation of immune complexes, which can be a pathophysiological cause of the immune response.
Highlights
This work is a fragment of KhMAPO «Cellular-molecular mechanisms of inflammation associated with chronic diseases», the state registration number 015U001186 "Pathochemical mechanisms of action of radioiodine on the organism and principles of their early diagnosis and correction", state registration number 0117U000589
According to the results of our study, we hypothesized that platelet derivatives of microparticles (PMP) can interact with circulating autoantibodies and C1q involved in the formation of immune complexes, which can be a pathophysiological cause of the immune response
Participation of platelets in autoimmune diseases has been extensively disclosed in the scientific literature, and their disrupted functioning is a sign of idiopathic thrombocytopenic purpura (ITP), rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome and multiple sclerosis and many other diseases [1,2]
Summary
This work is a fragment of KhMAPO «Cellular-molecular mechanisms of inflammation associated with chronic diseases», the state registration number 015U001186 "Pathochemical mechanisms of action of radioiodine on the organism and principles of their early diagnosis and correction", state registration number 0117U000589. Studies show that people with autoimmune thyroid disease (AIT) are prone to developing other autoimmune diseases and cardiovascular diseases. These include ITP and thrombocytopenia, associated with disorders in the structure and function of platelets [3]. Blood platelets are multifunctional blood cells that are involved in the initiation of atheroma, endothelial dysfunction, and modulation of inflammatory and immune responses [4]. Due to their multifaceted proinflammatory activity, platelets can be involved in the pathogenesis of autoimmune diseases of the thyroid gland. There is no data on the activity of platelets and their pathophysiological significance in autoimmune diseases of the thyroid gland [5,6,7,8]
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