Pathogenetic influence of liver steatosis in patients with hemorrhagic vasculitis: correlation analysis

Abstract

According to own data, 74% of patients with hemorrhagic vasculitis have sonographic signs of liver steatosis, but its influence on clinical and laboratory parameters of vasculitis is not established yet.
 The aim – to reveal the pathogenetic links of liver steatosis influence using correlation analysis, which could help in the planning of management strategy.
 Matherial and methods. We retrospectively analyzed the data of 50 inpatients with the help of Pearson’s correlation analysis.
 Results. In patients with hemorrhagic vasculitis, liver steatosis was more prominent in older ones and in higher body weight patients. Liver steatosis was accompanied by more significant changes in the right ventricle, left atrium, and aorta. It was also associated with systemic inflammation activity, serum proteolytic and thrombotic activity. In patients with liver steatosis, their age – a non-modifiable cardiovascular risk factor – was strongly associated with the deterioration of heart condition and changes of serum proteolytic and thrombotic activity, which, in turn, creates the background for adverse cardiovascular events. Liver steatosis was accompanied by the activation of systemic inflammation, which led to the transformation into steatohepatitis.
 Conclusion. The influence onto the liver steatosis is the only way of prevention of cardiovascular events and steatohepatitis in patients with hemorrhagic vasculitis.