Pathogenetic Concepts of the Malabsorption Syndrome

Abstract

The malabsorption syndrome discussed in this paper is characterized by defective absorption of nutrients from the upper small in. testine and the passage of an excessive amount of long chain fat in the stools, which may also be bulky, pale, fluid, and offensive, in the absence of previous surgery or obvious causative pathology. Other features of the syndrome may include lassitude, anorexia, loss of weight, anemia, ulcerated tongue, or buccal mucous membrane, bone changes, or stunted growth. In presenting the pathogenetic concepts of the malabsorption syndrome, consideration will first be given to the possible causes and significance of the changes in the stools, which may be common to all forms of the syndrome. Secondly, three conditions associated with the malabsorption syndrome will be discussed, in each of which the absorptive defect is due to a different cause. These are pancreatic enzyme deficiency, gluten-induced enteropathy, and sprue as seen in Hong Kong. Thirdly, the etiology and possible significance of the other features of the syndrome will be considered.