Abstract
In inbred mice of a low leukemic strain, dd, urethan was proved to induce thymic lymphoma when it was repeatedly administered early in life. At the age of 135 to 150 days the incidence of the tumor was 6/23 in males and 12/24 in females. In 8 males (8/17) and 6 females (6/12) of mice macroscopically free of the tumor, the thymus revealed microscopically early neoplastic changes. Thus the cumulative incidence of both neoplastic and early neoplastic cases was 14/23 for males and 18/24 for females. The urethan-induced thymic lymphoma was similar, in both histological characteristics and histogenesis, to that induced by other agents. The early lymphomatous changes appeared as replenishment with immature lymphocytes in the cortex after depletion of cortical small lymphocytes. The changes preceding lymphoma were often found in one lobe only of the thymus.
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