Pathogenesis of Psoriatic Pruritus

Abstract

Pruritus is a common symptom of most primary skin diseases and some systemic diseases. Despite the high incidence of pruritus in patients with psoriasis,the specific pathogenesis is complex and unclear. The occurrence and development of skin pruritus in psoriasis patients involve the joint participation of nervous,immune,endocrine,and vascular systems.This article reviews the mediators related to the pathogenesis of pruritus in psoriasis,aiming to improve the understanding of itching symptoms and the treatment of pruritus.