Pathogenesis of oncogenic simian adenoviruses: VIII. The histopathology and ultrastructure of simian adenovirus 7-induced intracranial neoplasms

Abstract

A high incidence of intracranial (I.C.) neoplasms occurred following inoculation of simian adenovirus 7 (SA7) into newborn hamsters. The neoplasms appeared most often to originate from the choroid plexus; however, other I.C. sites were observed. Although several histopathological patterns of these neoplasms were noted, an undifferentiated type pattern usually predominated. Virus-like particles were noted by electron microscopy within in vivo and in vitro neoplastic cells. These particles were morphologically similar to those observed within neoplastic cells “superinfected” by SA7. Annulate lamellae were observed within in vivo and in vitro neoplastic cells.