Abstract
Immune thrombocytopenic purpura(ITP) is a common autoimmune disorder characterized by isolated thrombocytopenia.Previous studies showed that autoantibodies bind to platelets and megakaryocytes playing a significant role in phagocytosis and depressing their maturation, which was the classic humoral immune mechanism. At present, the role of cellular immunity in the pathogenesis of ITP is more and more important. The abnormality of apoptosis of platelets and megakaryocytes also affects the incidence of ITP, abnormal protein of some kinds of cell subsets and abnormal levels of cytokines are confirmed in patients with ITP, and related researches on the gene of ITP patients has also made some progress. In addition, semaphorin (Sema) 5A and vitamin D3 abnormalities are also involved in pathogenesis of ITP. This article summarizes the research progress of ITP pathogenesis mainly from the humoral immunity, cellular immunity, apoptosis, gene expression, oxidative stress and other aspects. Key words: Purpura, thrombocytopenic, idiopathic; Immunity, humoral; Immunity, cellular; DNA methylation; Oxidative stress
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