Abstract
The human immunodeficiency virus type 1 (HIV-1) establishes a chronic, lifelong infection finally leading to the acquired immunodeficiency syndrome (AIDS), which is characterized by the onset of opportunistic infections and tumors. The natural course of HIV-1 infections is very variable and depends on the virus and its replication competence as well as the host. This review summarizes our current knowledge on HIV-1 and host factors influencing the pathogenesis of HIV-1.
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