Pathogenesis of Fever in Man

Abstract

FOR centuries before the introduction of the thermometer, fever was a well recognized sign of disease. During the Age of Pericles (ca. 450 B.C.) physicians accurately described the physical findings associated with the fevers of typhoid and other infections. However, only during the past three decades has the mechanism by which disease causes a rise in body temperature begun to be clarified. Studies in animals and in human beings have expanded knowledge of the pathogenesis of fever, and, more recently, information has been obtained at the molecular level. This report reviews established concepts and presents newer information on the pathogenesis . . .