Abstract
Proteins may undergo glycosylation by enzymatic or nonenzymatic mechanism. 1 Nonenzymatic glycosylation of proteins can occur under physiological conditions. Nonenzymatic glycosylation of hemoglobins (Hbs) results in the formation of Hb A 1a , Hb A 1b , and Hb A 1c , which are collectively known as glycosylated hemoglobins. Hemoglobin A 1c is the Amadori reaction product of the N -terminal valine of each β-chain of Hb A with glucose. 2 Hemoglobin A 1c has been extensively used as a measure of metabolic control in diabetic patients. 1 The degree of control of hyperglycemia as evaluated by the concentration of Hb A 1c in blood has been found to correlate with the occurrence of diabetic complications, particularly vasculopathy. 3 Brancati, 4 in an excellent, thought-provoking editorial in the April 10, 1995, issue of theArchivesdiscussed many aspects of the benefits of tight glycemic control in diabetes mellitus. However, the role that Hb
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