Pathogenesis of congenital cardiac malformations and mechanisms of cardiac remodelling

Abstract

At first sight, the venous and arterial poles of the heart seem to belong to a single structure. This feature is demonstrated by the continuity seen in the fibrous skeleton between the leaflets of the aortic valve with those of both the mitral and tricuspid valves. Moreover, the orifice of the aortic valve is deeply wedged in between the fibrous annuluses supporting the two atrioventricular valves.