Abstract
This review highlights recent reports on the diagnosis and treatment of precocious puberty. Diagnostic evaluation should include radiologic studies (particularly magnetic resonance imaging) to find a central nervous system-related cause, such as hypothalamic hamartoma, empty sella, or posttraumatic injury. Evaluation should also include laboratory tests for chorionic gonadotropin-secreting tumors (in boys), accurate measurement of pituitary gonad, and pelvic ultrasonography. Management of luteinizing hormone-releasing hormone (LHRH)-dependent precocious puberty with an LHRH agonist improves predicted adult height. Treatment is most convenient with monthly injections of a depot form of LHRH analogue. Although treatment with LHRH analogue usually reverses the puberty-induced increase in growth hormone secretion, growth hormone secretion usually remains appropriate for body mass index, and growth hormone treatment is not indicated.
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