Abstract
The entry of HPV into the epithelial cells begins the replication cycle. Depending on the HPV type, several cell receptors have been proposed as involved in HPV attachment. Once inside the epithelial cells HPV DNA replicates, leading to the activation of a cascade of viral gene expression. The E6 and E7 proteins of the high-risk HPV types act as viral oncoproteins by facilitating viral replication. The E4 and E5 proteins have been involved in the regulation of late viral functions, while E1 and E2 gene products block transcription of the E6 and E7 genes and permit the E1 gene product to initiate viral genome replication.
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