Abstract
Microbial Signaling Clinical isolates of the opportunistic pathogen Pseudomonas aeruginosa from cystic fibrosis patients often have mutations that affect the two-component systems—the signaling modules in bacteria. Cao et al. found that mutations in P. aeruginosa strains adapted to cystic fibrosis patients resulted in disruption of a two-component system and aberrant cross-talk between distinct two-component systems. These changes enabled the strains to switch from an acute to chronic infection state and allowed the activation of a two-component system by glucose, which is abundant in the lungs of cystic fibrosis patients. Sci. Signal. 13 , eaaz1529 (2020).
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