Abstract
Whooping cough (pertussis) is a highly contagious vaccine preventable respiratory disease caused by the Gram-negative bacterium Bordetella pertussis. Despite high level vaccination coverage over the past 20 years, Australia has one of the highest per capita burdens of pertussis globally. One of the primary factors associated with the re-emergence of pertussis is pathogen adaptation of B. pertussis to the current acellular vaccines used. This article will focus on the genomic and proteomic changes that have occurred in the Australian B. pertussis population, the significance of these adaptive changes on fitness in a vaccinated environment and what we can do to reduce the significant burden of pertussis in the future.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.