Pathobiology of Blast Injury

Abstract

Injury due to explosive detonation has previously been isolated to industrial accidents and soldiers and civilians in areas of armed military action. Substantial data regarding blast-related patterns of injury has come from military reports and research, and there have been significant advances in protective vehicle and body armor, ‘far forward’ provision of medical care, and evacuation procedures. Despite this, explosive munitions and improvised explosive devices still comprise the majority of combat morbidity and mortality [1]–[4]. There is also increased targeting of civilians in a global political environment where incendiary devices are a principle instrument of modern terrorism [5]–[7]. Events in preceding decades indicate a critical need for both civilian and military emergency and intensive care providers to understand the pathophysiology and management of blast-related injuries.