Abstract
The authors revise the concept of ALK-negative anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated as well as the phenotypic, molecular and clinical characteristics. Finally, the biological rationale for possible innovative targeted therapies is presented.
Highlights
anaplastic large cell lymphoma (ALCL) of the Hodgkin-like type deserves special attention.[17]
The authors revise the concept of ALK-negaly tive anaplastic large cell lymphoma (ALCL) in n the light of the recently updated World Health Organization o (WHO) classification of Tumors of Hematopoietic and Lymo phoid Tissues both on biological and clinical grounds
It was originally described as a form of the tumor, presenting in young people with a bulky mediastinal mass and consisting of anaplastic cells arranged in nodules surrounded by sclerotic bands, as seen in nodular sclerosing Hodgkin’s lymphoma (NSHL).[17]
Summary
ALCL of the Hodgkin-like type deserves special attention.[17]. It was originally described as a form of the tumor, presenting in young people with a bulky mediastinal mass and consisting of anaplastic cells arranged in nodules surrounded by sclerotic bands, as seen in nodular sclerosing Hodgkin’s lymphoma (NSHL).[17].
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