Path analysis of resilience and anxiety, depression on quality of life among esophageal carcinoma patients undergoing radiotherapy and (or) chemotherapy

Abstract

Objective To explore the impact of resilience and anxiety, depression on quality of life (QOL) among esophageal carcinoma patients undergoing radiotherapy and (or) chemotherapy. Methods A total of 125 patients were recruited into our study. Date were collected by European Organization for Research and Treatment of Cancer, Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) , Resilience Scale (RS) and Hospital Anxiety and Depression Scale (HADS). Analysis of Moment Structures (AMOS) version 7.0 software was used to conduct the path analysis. Results The total score of patients' QOL, RS and HADS were (51.98±19.42)points, (56.32±17.09)points, (14.59±7.04) points. Pearson's analysis showed that QOL was correlated with RS and HADS (r =0.423-0.588, P <0.05). RS was negatively correlated with HADS (path coefficient was-0.76 and -0.37) and HADS negatively correlated with QOL (path coefficient was -0.56 and -0.79). RS as a protective factor indirectly influenced QOL via HADS and the paths' total coefficients was 0.69. Conclusions The level of QOL and RS were at poor level for esophageal carcinoma patients, as well as participants experienced anxiety and depression. HADS as intermediary variable has a greater moderating effect on relationships between RS and QOL. RS is a indirect protective factor of QOL. Interventions developed on the basis of influencing factors of QOL should be applied to improve patients' integral health status. Key words: Esophageal carcinoma; Quality of life; Resilience, psychological; Anxiety; Depression