PATH-04. CURRENT STATUS AND PROSPECTS OF MALIGNANT BRAIN TUMOR TREATMENT IN CANCER GENOMIC MEDICINE

Abstract

Abstract INTRODUCTION The cancer gene panel test was covered by insurance in June 2019 in Japan. Our institution started the test in May 2020 and has experienced 16 cases. We will report on the current status and future prospects. METHODS The subjects were 16 patients (Average age 48.4) who underwent the cancer gene panel test with FoundationOne CDx. [Results] The cases included 9 glioblastomas, 3 anaplastic astrocytomas, 2 anaplastic oligodendrogliomas, an ependymoma, and a pituitary carcinoma. On average, 11.0 genetic changes were detected totally, oncogene mutations were 4.4, and gene mutations of unknown relevance to cancer were 5.6. Major oncogene mutations were IDH1 mutation in 5 cases, ATRX mutation in 2 cases, TP53 mutation in 9 cases, CDKN2A/2B mutation in 5 cases, and BRAF V600E mutation in 1 case. Based on our results, a 25-year-old man with BRAF V600E mutation and a 47-year-old male with IDH1 mutation could be given molecular-targeted drugs. Furthermore, a 59-year-old male with pituitary carcinoma had more than 10 mut/Mb in tumor mutational burden (TMB), indicating that anti-PD-1 antibody drugs can be administered. The chance of finding an appropriate drug by cancer gene panel test is approximately 10-20%. In cases that are resistant to standard treatment, the benefits can be expected if the drugs associated with the cancer gene panel test can be used. CONCLUSIONS Comprehensive cancer gene panel test has the potential to provide personalized medicine. And we suggest that the active use of cancer gene panel test may contribute to the development of new drugs with high response rates and the improvement of prognosis.