Paternalism and the ACMG recommendations on genomic incidental findings: patients seen but not heard

Abstract

To the Editor: Incidental findings that may arise in whole-exome or whole-genome sequencing pose significant challenges for clinical care. The American College of Medical Genetics and Genomics’ (ACMG’s) recent article, “ACMG Recommendations for Reporting of Incidental Findings in Clinical Exome and Genome Sequencing,” establishes routine analysis of pathogenic variants of a list of disease-associated genetic loci as a standard of practice when clinical whole-genome sequencing is done for any reason except prenatal testing.