Abstract
We previously established a murine model to explore the adult consequences of developmental TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) exposure. Using this model, we demonstrated that adult male offspring (F1) of toxicant exposed dams exhibit testicular inflammation, reduced sperm count, altered sperm morphology and subfertility. Control partners of F1 males that were able to become pregnant exhibit placental inflammation and an increased risk of spontaneous preterm birth. Our studies also demonstrated reduced placental and pup weight in pregnancies arising from F1 males compared to controls, suggesting paternal toxicant exposure is associated with placental dysfunction.
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