Abstract
This review summarises patents claiming novel DNA gyrase inhibitors (quinolones and non-quinolones) published from January 1995 to date. The majority of these patents describe the synthesis and biological evaluation of new fluoroquinolone analogues with modified substituents on N-1, C-5, C-7 or C-8 of the quinolone ring system. A series of quinolizinones were reported as potent broad-spectrum antibacterial agents with activity against several resistant bacterial strains. Two interesting non-quinolone inhibitors with new chemotypes were reported. However, no detailed reports on biological profiles were described. Several patents relating to the improved synthesis of quinolone intermediates were also published. The last group of patents reported new formulation methods for known quinolones, which claimed to provide improved physical stability or improved therapeutic efficacy. New applications of known fluoroquinolones against aphthous ulcers and human immunodeficiency virus (HIV) were also claimed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
