Abstract
Type III receptor tyrosine kinase, e.g., PDGFR, are associated with various autoimmune diseases. To show thestatus of PDGFR and c-KIT targets, we performed the US patent analysis. The present study showed that the R&D of c-KIT target was much earlier than the R&D of PDGFR targets. Currently, thePDGFR-based target demonstratesmore applications in the development of biological therapy. Our findings indicated that some inhibitors of c-KIT target contained sulfur elements or 1,3-diazine rings. The c-KIT target has more competitive edges for chemical drug discovery than the PDGFR target. c-KIT and PDGFR targets are currently preferable for drug discovery in autoimmune diseases. This study wasthe first to show R&D differentiation between PDGFR and c-KIT targets in drug development.
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