Abstract
A recent publication [ [1] Allemann Y. Hutter D. Lipp E. et al. Patent foramen ovale and high-altitude pulmonary edema. JAMA. 2006; 296: 2954-2958 Crossref PubMed Scopus (102) Google Scholar ] described patent foramen ovale (PFO) being four to five times more frequent in subjects with high-altitude pulmonary edema (HAPE) than those without and the size of PFO being directly related to hypoxemia. These findings serve as another strong argument in favor of closure of all PFOs [ [2] Cheng T.O. That balloon atrial septostomy is associated with preoperative stroke in neonates with transposition of the great arteries is another powerful argument in favor of therapeutic closure of every patent foramen ovale. Am J Cardiol. 2006; 98: 277-278 Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar ].
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