Patent ductus arteriosus in infants <28 weeks gestation

Abstract

Journal of Paediatrics and Child HealthVolume 50, Issue 4 p. 323-323 Heads UpFree Access Patent ductus arteriosus in infants <28 weeks gestation First published: 03 April 2014 https://doi.org/10.1111/jpc.12533 edited by Craig Mellis ([email protected]) AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat The management of patent ductus arteriosus (PDA) in preterm infants is controversial. A Danish single-centre cohort study routinely screened infants <32 weeks gestation with echocardiography for PDA on day 3 of life.1 The study assessed the association between PDA diameter and various adverse outcomes. It also distinguished between small (diameter <1.5 mm) and large PDA (≥1.5 mm) and compared infants born <28 weeks gestation with those born ≥28 weeks. Thirty-two (31%) of 104 neonates ≥28 weeks had PDA, but there was no association between PDA and adverse outcome. In contrast, PDA was present in 52 (66%) of 79 neonates <28 weeks gestation and associated with more than triple the risk of death or severe morbidity (odds ratio (OR) = 3.4, 95% confidence interval (CI) 1.1, 11). The risk was highest in infants with large PDA (≥1.5 mm), who also had an increased risk of intraventricular haemorrhage (OR = 4.2, 95% CI 1.3, 14) and bronchopulmonary dysplasia (OR = 3.7, 95% CI 1.0, 14). The authors do not suggest that PDA closure would improve outcome but suggest that routine early echocardiography could identify infants with PDA who could be enrolled in clinical trials evaluating duct closure. Reference 1 Sellmer A et al. Morbidity and mortality in preterm neonates with patent ductus arteriosus on day 3. Arch. Dis. Child. Fetal Neonatal Ed. 2013; 98: F505– 510. Reviewer: David Isaacs, [email protected] Volume50, Issue4April 2014Pages 323-323 ReferencesRelatedInformation